2,3,6-三甲基苯酚一步氧化制备2,3,5-三甲基-1,4-苯醌研究进展

2,3,6-三甲基苯酚一步氧化制备2,3,5-三甲基-1,4-苯醌相对于传统的磺化-氧化法具有产品收率高、过程简单、条件温和以及环境友好等特点。本文针对2,3,6-三甲基苯酚一步氧化制备2,3,5-三甲基-1,4-苯醌的均相催化氧化和非均相催化氧化工艺进行了综述,对两种工艺的发展过程及研究现状进行了评价及总结。详细讨论了不同方法和路线在催化活性、选择性以及产品分离和催化剂回收等方面的优缺点,简要分析并总结了2,3,6-三甲基苯酚一步氧化研究的发展规律和最新动态,展望了以非均相催化反应机制为重点的微观机理研究和以提高催化剂循环稳定性、降低制备成本为重点的工业化探索两个潜在的发展方向。

Research progress on the synthesis of 2,3,5-trimethyl-1,4-benzonquinone from one-step oxidation of 2,3,6-trimethylphenol

One-step oxidation of 2,3,6-trimethylphenol to 2,3,5-trimethyl-1,4-benzonquinone has many advantages over traditional sulfonated-oxidation process with higher yield,simpler and midler reaction condition and environment benign. Recent progresses on homogeneous and heterogeneous catalytic oxidation of 2,3,6-trimethylphenol were introduced and reviewed. The advantages and disadvantages of each method and route in catalytic activity,selectivity,product separation and catalyst recovery were discussed. The latest trends and development were analyzed and summarized. Micromechanism research on heterogeneous catalysis and industrialization exploration on catalyst cost and cyclical stability were considered as two potential research directions.