| 直接环合制备2-氯-5-氯甲基吡啶 |
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| 引用本文： | 温自强,高中良,周彦峰,邱继平.直接环合制备2-氯-5-氯甲基吡啶[J].化工中间体,2007(12):18-20. |
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| 作者姓名： | 温自强 高中良 周彦峰 邱继平 |
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| 作者单位： | 河北工业大学,化工学院,天津,300310 |
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| 摘 要： | 2-氯-5-氯甲基吡啶是合成吡虫啉和腚虫脒等杀虫剂的关键中间体。研究了一种直接环合的方法,用2-氯-2氯甲基-4-氰基丁醛与三氯氧磷反应来制备2-氯-5-氯甲基吡啶。通过正交实验优化了反应条件,2-氯-5-氯甲基吡啶的产品纯度可以达到95%以上。
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| 关 键 词： | 2-氯-5-氯甲基吡啶 2-氯-2-氯甲基-4-氰基丁醛 环合反应 |
| 文章编号： | 1006-253x（2007）12-018-3 |
| 收稿时间： | 2007-09-24 |
| 修稿时间： | 2007年9月24日 |
Synthesis of 2-Chloro-5-chloromethylpyridine by Direct Cyclization |
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| Authors: | WEN Zi-qiang GAO Zhong-liang ZHOU Yan-feng QIU Ji-ping |
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| Affiliation: | WEN Zi-qiang, GAO Zhong-liang, ZHOU Yan-feng, QIU Ji-ping (College of Chemical Engineering, Hebei University of Technology, Tianjin 300130, China) |
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| Abstract: | 2-Chloro-5-chloromethylpyridine is the key intermediate of insecticide such as imidacloprid and acetamiprid. A synthetic method of direct cyclization was researched that 2-chloro-2- chloromethyl-4-cyanobutyraldehyde was reacted with phosphorus oxychloride to get 2-chloro-5- chloromethylpyridine. The conditions were optimized via orthogonal experiments, a high purity of 2- chloro-5-chloromethylpyridine could be achieved and the purity was above 95%. |
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| Keywords: | 2-chloro-5-chloromethylpyridine 2-chloro-2-chloromethyl-4-cyanobutyraldehyde cyclization |
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