The time course of visuospatial processing deficits in schizophrenia: An event-related brain potential study.

Event-related brain potentials (ERPs) were recorded during a dot enumeration task so as to investigate electrophysiologic correlates of early visuospatial processing in schizophrenia. Twenty-eight patients having a diagnosis of schizophrenia (n?=?19) or schizoaffective disorder (n?=?9) and 28 controls were tested. Patients showed poorer dot enumeration than did controls and also had markedly reduced early negative ERPs, which began about 150 ms after stimulus onset at the peak of the N1 potential and reached its maximum about 275 ms at the N2 peak. The N1 reduction in patients was greatest over left parietal sites for stimuli in the right visual field. The marked N1 and N2 reductions in patients are supportive of models postulating deficits in early visuospatial attention and allocation of conceptual resources in schizophrenia. (PsycINFO Database Record (c) 2010 APA, all rights reserved)