Supercritical carbon dioxide–assisted synthesis of stimuli-responsive magnetic poly(N-isopropylacrylamide)–ferrite biocompatible nanocomposites for targeted and controlled drug delivery |
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| Authors: | Gunjan Bisht M G H Zaidi Sagar Rayamajhi |
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| Affiliation: | 1. Department of Chemical Science and Engineering, School of Engineering, Kathmandu University, Dhulikhel, Nepal;2. Department of Chemistry, College of Basic Science, G. B. Pant University of Agriculture and Technology, Pantnagar, India;3. Department of Biotechnology, School of Science, Kathmandu University, Dhulikhel, Nepal |
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| Abstract: | Supercritical carbon dioxide–assisted synthesis of poly(N-isopropylacrylamide)–ferrite nanocomposites was carried out by polymerization reaction of N-isopropyl acrylamide monomer in the presence of ferrite nanoparticles. They were characterized by Fourier transform infrared, X-ray diffraction, transmission electron microscopy, atomic force microscopy, and vibrating sample magnetometry analysis. Drug loading and release profiles were studied. Nanomaterials showed pH-dependent drug release profile. Polymer nanocomposites in comparison to ferrite nanoparticles showed impressive drug release activity, with a release percent of 20.98–76.54%, and greater biocompatibility in breast cancer cells, with a cell viability of 81–93%. This pH-dependent drug release activity and magnetic property of polymer nanocomposites can be used for controlled and targeted drug delivery. |
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| Keywords: | Biocompatible doxorubicin drug release kinetics magnetic polymer nanocomposites poly(N-isopropylacrylamide) supercritical synthesis targeted delivery |
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