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A Bimetallic Nanozyme with Cascade Effect for Synergistic Therapy of Cancer |
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| Authors: | Xiaoqing Li Dr. Yue Cao Dr. Bo Xu Dr. Ying Zhao Dr. Tianqi Zhang Prof. Yinghui Wang Prof. Daguang Wang Prof. Jianhua Liu Prof. Shuyan Song Prof. Hongjie Zhang |
| Affiliation: | 1. State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 130022 Changchun, China School of Applied Chemistry and Engineering, University of Science and Technology of China, 230026 Hefei, China;2. The First Hospital of Jilin University, 130021 Changchun, China;3. The Second Hospital of Jilin University, 130041 Changchun, China;4. State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 130022 Changchun, China;5. State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 130022 Changchun, China School of Applied Chemistry and Engineering, University of Science and Technology of China, 230026 Hefei, China Department of Chemistry, Tsinghua University, 100084 Beijing, China |
| Abstract: | Novel nanocomposites were constructed through encapsulation of Au nanoparticles and Ru nanoparticles into dendritic mesoporous silica (DMSN-Au-Ru NPs). These exhibit improved effects due to a cascade catalytic ability for the synergistic therapy of cancer. Au nanoparticles with glucose oxidase-like properties were found to catalyze the oxidation of glucose to produce H2O2, while Ru nanoparticles could decompose H2O2 and produce toxic 1O2 for improved photodynamic therapy (PDT). In addition, the nanocomposites were found to have good photothermal performance under irradiation by near-infrared (NIR) light. Both in vitro and in vivo experiments show that the nanocomposites have good therapeutic effects due to the cascade catalytic effect and synergistic effect. These findings provide an effective way to design a new generation of nanodrugs for highly efficient cancer treatment. |
| Keywords: | nanozyme photodynamic therapy photothermal therapy cancer therapy |