Effects of Beverages on Alcohol Metabolism: Potential Health Benefits and Harmful Impacts |
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| Authors: | Fang Wang Yu-Jie Zhang Yue Zhou Ya Li Tong Zhou Jie Zheng Jiao-Jiao Zhang Sha Li Dong-Ping Xu Hua-Bin Li |
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| Affiliation: | 1.Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China; (F.W.); (Y.-J.Z.); (Y.Z.); (Y.L.); (T.Z.); (J.Z.); (J.-J.Z.); (D.-P.X.);2.School of Chinese Medicine, The University of Hong Kong, Hong Kong 999077, China; ;3.South China Sea Bioresource Exploitation and Utilization Collaborative Innovation Center, Sun Yat-Sen University, Guangzhou 510006, China |
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| Abstract: | Nonalcoholic beverages are usually consumed accompanying alcoholic drinks, and their effects on alcohol metabolism are unclear in vivo. In this study, the effects of 20 nonalcoholic beverages on alcohol metabolism and liver injury caused by alcohol were evaluated in mice. Kunming mice were orally fed with alcohol (52%, v/v) and beverages. The concentrations of ethanol and acetaldehyde in blood as well as the activities of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in liver were assessed to indicate alcohol metabolism. The levels of aspartate aminotransferase (AST) and alanine transaminase (ALT) in serum as well as the levels of malonaldehyde (MDA) and superoxide dismutase (SOD) in liver were measured to reflect the alcohol-induced liver injury. The results showed that the treatment of soda water, green tea and honey chrysanthemum tea could accelerate ethanol metabolism and prevent liver injuries caused by alcohol when companied with excessive alcohol drinking. They might be potential dietary supplements for the alleviation of harmful effects from excessive alcohol consumption. On the contrary, some beverages such as fresh orange juice and red bull are not advised to drink when companied with alcohol consumption due to their adverse effects on ethanol induced liver injury. |
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| Keywords: | nonalcoholic beverages alcohol metabolism hepatoprotection harmful impact |
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