Crosstalk between Autophagy and Apoptosis: Potential and Emerging Therapeutic Targets for Cardiac Diseases |
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| Authors: | Meng Li Ping Gao Junping Zhang |
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| Affiliation: | 1.Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; ;2.Department of Medical Imaging, Urumqi General Hospital of Lanzhou Military Area Command, Urumqi 830000, China; ;3.Department of cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medcine, Tianjin 300192, China |
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| Abstract: | Autophagy is a cell survival process which is related to breaking down and reusing cytoplasm components. Moreover, autophagy regulates cell death under certain conditions. Apoptosis has the characteristics of chromatin agglutination and the shrinking of nuclear and apoptosis body form. Even if the mechanisms of autophagy and apoptosis have differences, some proteins modulate both autophagy and apoptosis. Crosstalk between them exists. This review highlights recent advances in the interaction of autophagy and apoptosis and its importance in the development of cardiovascular diseases. |
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| Keywords: | autophagy apoptosis crosstalk cardiovascular diseases |
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