| 新橙皮苷二氢查耳酮工艺研究 |
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| 引用本文： | 肖乐扩,林英昌,王龙书. 新橙皮苷二氢查耳酮工艺研究[J]. 广东化工, 2014, 0(12): 55-56 |
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| 作者姓名： | 肖乐扩 林英昌 王龙书 |
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| 作者单位： | 广州白云山汉方现代药业有限公司,广东广州510970 |
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| 摘 要： | 以新橙皮苷为起始原料,制备新橙皮苷二氢查耳酮,通过对碱(氢氧化钠)用量、催化剂用量、反应温度、氢气压力、搅拌速度、反应时间等关键因素的单因素实验,对制备工艺进行了研究,建立了适用于工业化生产的方法,最佳合成的工艺为:新橙皮苷与氢氧化钠的质量比为1∶0.3,新橙皮苷与催化剂(阮尼镍)的质量比为1∶0.1,搅拌速度为150转/分钟,反应温度为25℃,反应时间为10小时。
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| 关 键 词： | 新橙皮苷 新橙皮苷二氢查耳酮 催化氢化 阮尼镍 |
Study on Process of Neohesperidin Dihydrochalcone |
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| Xiao Lekuo,Lin Yingchang,Wang Longshu. Study on Process of Neohesperidin Dihydrochalcone[J]. Guangdong Chemical Industry, 2014, 0(12): 55-56 |
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| Authors: | Xiao Lekuo Lin Yingchang Wang Longshu |
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| Affiliation: | (Guangzhou Hanfang Pharmaceutical Co., Ltd., Guangzhou 510970, China) |
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| Abstract: | The process for preparation of neohesperidin dihydrochalcone from neohesperid was investigated. The paper studied the several influenced factors： reaction time, the dosage of catalyst and NaOH, reaction solvent, hydrogen pressure, reaction temperature, stiring speed. The product was obtained under optimum conditions of temperature 25 ℃, stiring speed 150 R/min, and reaction time 10 b. The weight equivalence of NHDC, NaOH and raney nickel is 1 ： 0.3 ： 0.1. The process is more suitable for manufacturing with higher quality. |
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| Keywords: | neohesperidin；NHDC；catalytic hydrogen raneynickel |
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