急性颅脑损伤后血清高敏C反应蛋白、肌酸激酶同工酶MB水平的变化及其意义

目的探讨急性颅脑损伤后血清高敏C反应蛋白（high-sensitivity C-reactive protein,hs-CRP）和肌酸激酶同工酶MB（creatine kinase-MB,CK-MB）水平的变化及其意义。方法将107例患者按格拉斯哥昏迷（GCS）评分分为3组：轻型组（13～15分）46例、中型组（9～12分）30例和重型组（3～8分）31例。采用胶乳凝集反应法、使用全自动生化分析仪检测血清hs-CRP水平,采用免疫抑制法、使用全自动生化分析仪检测血清CK-MB水平。结果轻型组、中型组、重型组血清hs-CRP水平分别为（18.23±10.08）、（29.49±12.77）、（76.96±25.18）mg.L^-1,3组间血清hs-CRP水平比较差异均有统计学意义（均P〈0.05）;轻型组、中型组、重型组血清CK-MB水平分别为（29.44±6.72）、（41.83±9.01）、（70.39±18.52）U.L^-1,3组间血清CK-MB水平比较差异均有统计学意义（均P〈0.05）。急性颅脑损伤后血清hs-CRP、CK-MB水平与损伤程度均呈正相关（r=0.243、0.215,均P〈0.05）。结论血清hs-CRP和CK-MB检测对评估急性颅脑损伤程度有重要的意义。

Changes in Serum High-Sensitivity C-Reactive Protein and Creatine Kinase-MB Levels after Acute Craniocerebral Injury and Their Significance

Objective To investigate the changes in serum high-sensitivity C-reactive protein（hs-CRP） and creatine kinase-MB（CK-MB） levels after acute craniocerebral injury and their significance.Methods A total of 107 patients with acute craniocerebral injury were divided into three groups based on GCS scores：mild（GCS scores 13 to 15,n=46）,moderate（GCS scores 9 to 12,n=30）,and severe（GCS scores 3 to 8,n=31）.Hs-CRP was determined by the latex agglutination reaction and CK-MB was detected by immunosuppression.Results The hs-CRP levels were（18.23±10.08）,（29.49±12.77） and（76.96±25.18）mg·L^-1 in mild,moderate and severe groups,respectively,and the differences among the three groups were statistically significant（P0.05）.The CK-MB levels were（29.44±6.72）,（41.83±9.01） and（70.39±18.52） U·L^-1 in mild,moderate and severe groups,respectively,and the differences among the three groups were statistically significant（P0.05）.Serum hs-CRP and CK-MB levels were positively correlated with the degree of injury（r=0.243 and r=0.215,respectively;P0.05）.Conclusion The detection of serum hs-CRP and CK-MB levels has important significance for estimating the degree of acute craniocerebral injury.