| 甘氨酸衍生物氨肽酶抑制剂的合成 |
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| 引用本文： | 黄惠明,梁辉,李敏,陈根林,刘成梅.甘氨酸衍生物氨肽酶抑制剂的合成[J].矿产勘查,2011(3):8-12. |
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| 作者姓名： | 黄惠明 梁辉 李敏 陈根林 刘成梅 |
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| 作者单位： | [1]南昌大学食品科学与技术国家重点实验室,南昌330029 [2]南昌大学研究生院医学部,南昌330006 |
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| 摘 要： | 目的探讨甘氨酸衍生物类氨肽酶N（APN）抑制剂类抗肿瘤药物的合成。方法通过对已知的类肽类APN抑制剂结构特征的总结,设计并合成3个系列酰胺衍生物。结果通过IR、MS和1H-NMR确定其化学结构,所合成的化合物1a-f、2a-f和3a-f均未见报道,为新化合物。结论化合物3b可以作为APN的先导化合物。
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| 关 键 词： | 氨肽酶N抑制剂 甘氨酸衍生物 化学合成 |
Synthesis of Glycine Derivatives as Aminopeptidase Inhibitors |
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| HUANG Hui-ming,LIANG Hui,LI Min,CHEN Gen-lin,LIU Cheng-mei.Synthesis of Glycine Derivatives as Aminopeptidase Inhibitors[J].Mineral Exploration,2011(3):8-12. |
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| Authors: | HUANG Hui-ming LIANG Hui LI Min CHEN Gen-lin LIU Cheng-mei |
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| Affiliation: | (a.State Key Laboratory of Food Science and Technology,Nanchang 330029,China;b.Medical Department of Graduate School,Nanchang University,Nanchang 330006,China) |
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| Abstract: | Objective To explore the synthesis of glycine derivatives as aminopeptidase N（APN） inhibitors.Methods Based on the known structure of peptide-like derivatives as APN inhibitors,three series of acetamide derivatives were designed and synthesized.Results The chemical structure of acetamide derivatives was determined using IR,MS and 1H-NMR methods.The synthesized compounds 1a-f,2a-f and 3a-f were new compounds and had not be reported anywhere.Conclusion Compound 3b can be used as lead compound of APN. |
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| Keywords: | aminopeptidase N inhibitors glycine derivatives chemical synthesis |
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