| 乙酰肝素酶/多配体蛋白聚糖-1轴对癌细胞增殖的调控作用 |
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| 引用本文： | 于生金.乙酰肝素酶/多配体蛋白聚糖-1轴对癌细胞增殖的调控作用[J].辽东学院学报(自然科学版),2014(3):162-166. |
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| 作者姓名： | 于生金 |
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| 作者单位： | 辽东学院医学院,辽宁丹东118003 |
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| 基金项目： | 辽东学院自然科学研究青年基金项目（2013q002） |
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| 摘 要： | 多配体蛋白聚糖-1(Syndecan-1)是一种硫酸肝素类蛋白聚糖。乙酰肝素酶(Heparanase)是生物体内的内切糖苷酶,能够特异性降解Syndecan-1的硫酸乙酰肝素侧链。Heparanase在许多恶性肿瘤组织中表达增加,且Heparanase通过上调生长因子活性及改变Syndecan-1结构正调控肿瘤的恶性行为。肿瘤组织中Heparanase/Syndecan-1轴的形成在促进肿瘤组织的生长、扩散、血管生成等过程中发挥重要作用。针对Heparanase/Syndecan-1轴的抗肿瘤治疗在抑制恶性肿瘤生长方面具有良好的应用前景。
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| 关 键 词： | 多配体蛋白聚糖-1 乙酰肝素酶 癌症 细胞增殖 |
Regulation of Heparanase/Syndecan - 1 Axis to Proliferation of Cancer Cell |
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| Affiliation: | YU Sheng - jin ( College of Medicine, Eastern Liaoning University, Dandong 118003, China) |
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| Abstract: | Syndeean - 1 belongs to the member of heparan sulfate proteoglycans family. Heparanase is an en- doglucuronidase that cleaves heparan sulfate chains of syndecan - 1. In many malignancies, high expression and activity of heparanase correlate with an aggressive tumor phenotype. A major consequence of heparanase action in cancer is a robust up - regulation of growth factor expression and increased shedding of syndecan - 1. Heparanase and syndecan - 1 work together to form heparanase/syndecan - 1 axis, which drives growth factor signaling and ulates cell behaviors including tumor growth, dissemination, angiogenesis and osteolysis. Therapies targeting heparanase/syndecan - 1 axis hold promise for blocking the aggressive behavior of cancer. |
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| Keywords: | syndecan- 1 heparanase cancer proliferation |
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