聚果多酚抗衰老作用的实验研究

目的：观察聚果多酚的抗衰老作用。方法：将 32只18个月老龄大鼠随机分为2个剂量聚果多酚(50mg/kg和100mg/kg)、VE(35mg/kg)、老龄对照组，每日分别灌胃给与相应药物或生理盐水，连续给药16d，测定心肌脂褐素(LF) 、血浆超氧化物歧化酶 (SOD)、脂质过氧化物 (MDA)及血清总胆固醇(TC)和甘油三酯(TG) 、谷胱甘肽过氧化物酶(GSH-Px)活性。结果：给予聚果多酚大鼠血浆SOD和GSH-Px活力显著提高(p<0.01)，而MDA和LF含量则明显下降(p<0.05)。结论：聚果多酚能抑制自由基损伤，防止脂质过氧化，具有明显延缓衰老作用。

Study on Antiaging Function of Polyfruitnol

Polyfruitnol derived from blueberry, grapeseed, redwine and green tea was fortified with various vitamins and flavoring agents. The antiaging function of polyfruitnol to rat was investigated. 32 aging rats (18 months age) were randomly divided into 4 groups: 2 polyfruitnol-treated groups (50 and 100 mg/kg bw), VE group (35 mg/kg bw) and control group. All rats were administered with drugs or normal saline by gavage once a day for 16 days. After the administration, biochemical assay was conducted by measuring the activities of superoxide dismutase (SOD) in plasma and glutathione peroxidase (GSH-Px) in serum, and the contents of malodndaldegyde (MDA) in plasma, total cholesterol (TC) and triglyceride (TG) in serum and lipofuscin (LF) in heart. Results indicated that this polyfruitinol could significantly improve the activities of SOD and GSH-Px (p＜0.01) and is able to decrease the contents of the MDA and LF (p＜0.05), indicating that the polyfruitinol has certain antiaging function. The mechanisms may be associated with increasing the activities of antioxidation enzymes and preventing lipid peroxidation in tissues．