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Biomanufacturing of customized modular scaffolds for critical bone defects |
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| Authors: | Bahattin Koc Anil A. Acar Andrew Weightman Glen Cooper Gordon Blunn Paulo Bartolo |
| Affiliation: | 1. Faculty of Engineering and Natural Sciences, Sabanci University, Orhanli-Tuzla, Istanbul, 34956, Turkey;2. 3D Bioprinting Laboratory, Sabanci University Nanotechnology Research and Application Center, Orhanli-Tuzla, Istanbul, 34956, Turkey;3. School of Mechanical, Aerospace and Civil Engineering, Manchester Institute of Biotechnology, University of Manchester, Manchester, M13 9PL, UK;4. School of Pharmacy and Biomedical Sciences, University Portsmouth, Portsmouth, PO1 2UP, UK |
| Abstract: | There is a significant unmet clinical need for modular and customized porous biodegradable constructs (scaffolds) for non-union large bone loss injuries. This paper proposes modelling and biomanufacturing of modular and customizable porous constructs for patient-specific critical bone defects. A computational geometry-based algorithm was developed to model modular porous constructs using a parametric femur model based on the frequency of common injuries. The generated modular constructs are used to generate biomimetic path planning for three-dimensional (3D) printing of modular scaffold pieces. The developed method can be used for regenerating bone tissue for treating non-union large bone defects. |
| Keywords: | Corresponding author at: Faculty of Engineering and Natural Sciences, Sabanci University, Orhanli-Tuzla, Istanbul, 34956, Turkey. Additive manufacturing Biologically inspired design Biomanufacturing |
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