| 异丙隆半抗原的制备及鉴定 |
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| 引用本文： | 孙峰,李方实. 异丙隆半抗原的制备及鉴定[J]. 陶瓷科学与艺术, 2005, 0(6) |
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| 作者姓名： | 孙峰 李方实 |
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| 作者单位： | 南京工业大学理学院 江苏南京210009 |
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| 基金项目： | 国家自然科学基金资助项目(20447003) |
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| 摘 要： | 为了建立除草剂异丙隆的酶联免疫吸附测定(ELISA)方法,以对异丙基苯基异氰酸酯和N甲基已内酰胺为原料,经N甲基已内酰胺水解,而后与对异丙基苯基异氰酸酯反应,合成了与目标分子具有相似结构的异丙隆半抗原1(5戊基羧基)3(4异丙基苯基)1甲基脲。产物结构以红外及核磁等分析方法确认。为进一步研制异丙隆免疫抗体的制备奠定了基础。
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| 关 键 词： | 异丙隆 半抗原 合成 |
Synthesis and identification of the hapten for immunoassay of the phenyl-urea herbicide isoproturon |
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| SUN Feng,LI Fang-shi. Synthesis and identification of the hapten for immunoassay of the phenyl-urea herbicide isoproturon[J]. Ceramics Science & Art, 2005, 0(6) |
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| Authors: | SUN Feng LI Fang-shi |
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| Abstract: | In order to establish the immunoassay for the herbicide,isoproturon,hapten 1-(5-carboxypentyl)-3-(4-isopropylphenyl)-1-methylurea was synthesized from N-methylcaprolactam and p-isopropyl phenyl isocyanate.6-Methylaminohexanoic acid dehydrate was obtained by hydrolyzation of N-methylcaprolactam,and then reacted with p-isopropyl phenyl isocyanate to reach the target product.The structure of the product was confirmed by IR and ~1HNMR. |
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| Keywords: | isoproturon hapten synthesis |
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