CD39 Regulation and Functions in T Cells |
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Authors: | Eleonora Timperi Vincenzo Barnaba |
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Affiliation: | 1.Department of Immunology, PSL Research University, INSERM U932, Institut Curie, 26, rue d’Ulm, 75005 Paris, France;2.Department of Internal Clinical Sciences, Anaesthesiology and Cardiovascular Sciences, Sapienza Università di Roma, 00161 Rome, Italy;3.Laboratory Affiliated to Istituto Pasteur Italia—Fondazione Cenci Bolognetti, 00161 Rome, Italy |
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Abstract: | CD39 is an enzyme which is responsible, together with CD73, for a cascade converting adenosine triphosphate into adenosine diphosphate and cyclic adenosine monophosphate, ultimately leading to the release of an immunosuppressive form of adenosine in the tumor microenvironment. Here, we first review the environmental and genetic factors shaping CD39 expression. Second, we report CD39 functions in the T cell compartment, highlighting its role in regulatory T cells, conventional CD4+ T cells and CD8+ T cells. Finally, we compile a list of studies, from preclinical models to clinical trials, which have made essential contributions to the discovery of novel combinatorial approaches in the treatment of cancer. |
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Keywords: | adenosine CD39 CD73 regulatory T cells conventional CD4+ T cells CD8+ T cells single nucleotide polymorphism targeting therapy |
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