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Osteoarthritis-Related Inflammation Blocks TGF-β’s Protective Effect on Chondrocyte Hypertrophy via (de)Phosphorylation of the SMAD2/3 Linker Region |
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| Authors: | Nathalie Thielen Margot Neefjes Renske Wiegertjes Guus van den Akker Elly Vitters Henk van Beuningen Esmeralda Blaney Davidson Marije Koenders Peter van Lent Fons van de Loo Arjan van Caam Peter van der Kraan |
| Affiliation: | 1.Department of Experimental Rheumatology, Radboud University Medical Center, 6500 MD Nijmegen, The Netherlands; (N.T.); (M.N.); (R.W.); (E.V.); (H.v.B.); (E.B.D.); (M.K.); (P.v.L.); (F.v.d.L.); (A.v.C.);2.Department of Orthopedic Surgery, Maastricht University, 6200 MD Maastricht, The Netherlands; |
| Abstract: | |
| Keywords: | TGF-β osteoarthritis cartilage SMAD2/3 signaling linker modifications inflammation |