The Gut Microbiota-Derived Immune Response in Chronic Liver Disease |
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| Authors: | Sung-Min Won Eunju Park Jin-Ju Jeong Raja Ganesan Haripriya Gupta Yoseph Asmelash Gebru SatyaPriya Sharma Dong-Joon Kim Ki-Tae Suk |
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| Affiliation: | Institute for Liver and Digestive Diseases, Hallym University College of Medicine, Chuncheon 24253, Korea; or (S.-M.W.); (E.P.); (J.-J.J.); (R.G.); (H.G.); (Y.A.G.); (S.S.); (D.-J.K.) |
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| Abstract: | In chronic liver disease, the causative factor is important; however, recently, the intestinal microbiome has been associated with the progression of chronic liver disease and the occurrence of side effects. The immune system is affected by the metabolites of the microbiome, and diet is the primary regulator of the microbiota composition and function in the gut–liver axis. These metabolites can be used as therapeutic material, and postbiotics, in the future, can increase or decrease human immunity by modulating inflammation and immune reactions. Therefore, the excessive intake of nutrients and the lack of nutrition have important effects on immunity and inflammation. Evidence has been published indicating that microbiome-induced chronic inflammation and the consequent immune dysregulation affect the development of chronic liver disease. In this research paper, we discuss the overall trend of microbiome-derived substances related to immunity and the future research directions. |
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| Keywords: | chronic liver disease, gut microbiome, immune response, gut– liver axis |
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