| 人参皂苷Rg3与Rg5的分离及Rg3异构体的拆分 |
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| 引用本文： | 田桐,宋建国,赵慕,鱼红闪,金凤燮.人参皂苷Rg3与Rg5的分离及Rg3异构体的拆分[J].大连工业大学学报,2011,30(2):109-112. |
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| 作者姓名： | 田桐 宋建国 赵慕 鱼红闪 金凤燮 |
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| 作者单位： | 1. 大连工业大学,生物工程学院,辽宁,大连,116034
2. 大连工业大学,化工与材料学院,辽宁,大连,116034 |
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| 基金项目： | 国家自然科学基金，辽宁省教育厅创新团队项目 |
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| 摘 要： | 主要进行了从红参稀有皂苷20(S)Rg3、20(R)-Rg3、Rg5和Rk1混合物中分离单体皂苷的研究.根据混合物在甲醇中各组分的溶解度不同,先分离出20(R)-Rg3,然后采用硅胶柱层析法分离20(S)-Rg3、Rg5和Rk1.从30 g红参稀有皂苷混合物中得到7.40 g纯度为64.0%的20(R)-Rg3粗品;1...
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| 关 键 词： | 人参皂苷 分离 硅胶柱层析 结晶 |
Separation and preparation of ginsenosides Rg3 enantiomers and Rg5 |
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| TIAN Tong,SONG Jian-guo,ZHAO Mu,YU Hong-shan,JIN Feng-xie.Separation and preparation of ginsenosides Rg3 enantiomers and Rg5[J].Journal of Dalian Dalian Polytechnic University,2011,30(2):109-112. |
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| Authors: | TIAN Tong SONG Jian-guo ZHAO Mu YU Hong-shan JIN Feng-xie |
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| Affiliation: | 1.School of Bioengineering,Dalian Polytechnic University,Dalian 116034,China;2.School of Chemistry Engineering and Material,Dalian Polytechnic University,Dalian 116034,China |
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| Abstract: | Based on the solute difference in methanol,ginsenosides 20(S)-Rg3,20(R)-Rg3,Rg5 and Rk1 has been separated each other with silica gel column.7.40 g 20(R)-Rg3 with the purity of 64.0%,10.9 g 20(S)-Rg3 with the purity of 75.3%,and 6.05 g mixture of Rg5 and Rk1 were obtained from 30 g mixture.After that 20(S)-Rg3 and 20(R)-Rg3 were purified by crystallization and 0.850 g 20(S)-Rg3 with the purity of 95.1%,and 1.98 g 20(R)-Rg3 with the purity of 94.6% were obtained from 3 g 20(S)-Rg3 and 3 g 20(R)-Rg3 respectively. |
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| Keywords: | ginsenosides separation silica gel column crystallization |
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