Effect of long term ingestion of gum arabic on the adipose tissues of female mice |
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Authors: | Kazunari Ushida Hironori Hatanaka Ryo Inoue Takamitsu Tsukahara Glyn O. Phillips |
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Affiliation: | 1. Laboratory of Animal Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural Univeristy, Kyoto 606-8522, Japan;2. Kyoto Institute of Nutrition and Pathology, Ujitawara, Kyoto 610-0231, Japan;3. Glyn O. Phillips Hydrocolloid Research Center, Glynd?r University, Plas Coch, Mold Road, Wrexham LL11 2AW, UK;4. Phillips Hydrocolloids Research Ltd, 45 Old Bond Street, London W1S 4QT, UK |
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Abstract: | Abdominal obesity is the most prevalent manifestation of metabolic syndrome. The anti-obese effects of dietary fiber is generally accepted, but specifically the anti-obese properties of the dietary fiber, gum arabic (GA) has not been well studied. In this investigation, we offered GA to the female 90 days old mice in the form of drink (1% w/v) for 180 days. Such GA in drinking water reduced age-dependent fat deposition in the visceral adipose tissue and improved the gastrocnemius muscle reduction. This inhibition of fat deposition effect is due to the β3-adrenergic stimulation of adipocytes in which TNFα down-regulation is probably involved. Modification of large intestinal microflora, as evidenced by a modification of cecal short-chain fatty acid profile and of 16S rDNA profile, may contribute to such reduction in TNFα expression in the adipose tissues. |
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Keywords: | Gum arabic Anti-obesity β3-adrenergic stimulation TNFα down-regulation |
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