| 西尼地平的合成工艺研究 |
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| 引用本文： | 施务务,李立标.西尼地平的合成工艺研究[J].安徽化工,2014(5):33-34. |
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| 作者姓名： | 施务务 李立标 |
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| 作者单位： | 1. 蚌埠市第一人民医院药学部,安徽蚌埠,233000
2. 蚌埠丰原医药科技发展有限公司,安徽蚌埠,233000 |
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| 摘 要： | 以乙酰乙酸甲氧基乙基酯、乙酰乙酸肉桂醇酯为起始原料,经中间体3-氨基巴豆酸肉桂醇酯,通过Aldol缩合、Hantzsch环合反应,合成出了钙离子拮抗剂西尼地平。该合成工艺安全可行,操作简单,适合工业化生产。
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| 关 键 词： | 西尼地平 钙拮抗剂 合成 |
Study on the Synthesis Technology of Cilnidipine |
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| SHI Wu-wu,LI Li-biao.Study on the Synthesis Technology of Cilnidipine[J].Anhui Chemical Industry,2014(5):33-34. |
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| Authors: | SHI Wu-wu LI Li-biao |
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| Affiliation: | SHI Wu-wu;LI Li-biao;First People’s Hospital of Bengbu City;Bengbu BBCA Pharmaceutical Technology Development Co., Ltd.; |
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| Abstract: | With 2-methoxyethyl acetoacetate and cinnamyl acetoacetate as the starting materials, the cilnidipine can be obtained from 3-Aminocrotonic Cinnamate by Aldol condensation and Hantzsch cyclization. It is a suitable way to produce cilnidipin industrially,which provides the advantage of simplicity and safety. |
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| Keywords: | cilnidipine dihydropyridine calcium antagonist synthesis |
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