| 2-（3-氯吡啶-2-基）-5-羟基吡唑-3-甲酸乙酯的合成 |
| |
| 引用本文： | 叶俊,段红玉,姚日生.2-（3-氯吡啶-2-基）-5-羟基吡唑-3-甲酸乙酯的合成[J].安徽化工,2014(5):16-17,20. |
| |
| 作者姓名： | 叶俊 段红玉 姚日生 |
| |
| 作者单位： | 合肥工业大学医学工程学院,安徽合肥,230009;合肥工业大学医学工程学院,安徽合肥,230009;合肥工业大学医学工程学院,安徽合肥,230009 |
| |
| 摘 要： | 2-(3-氯吡啶-2-基)-5-羟基吡唑-3-甲酸乙酯是合成氯虫酰胺杀虫剂的一种重要中间体。以2,3-二氯吡啶为原料经肼解、环合两步反应合成2-(3-氯吡啶-2-基)-5-羟基吡唑-3-甲酸乙酯,并对其工艺做了改进和优化,总收率43.1%。其中,3-氯-2-肼基吡啶采用无溶剂法合成,工艺过程简单。
|
| 关 键 词： | 2-(3-氯吡啶-2-基)-5-羟基吡唑-3-甲酸乙酯 3-氯-2-肼基吡啶 合成 无溶剂法 |
The Synthesis of Ethyl 2-(3-chloro-2-yl)-5-hydroxy-pyrazole-3-carboxylate |
| |
| YE Jun,DUAN Hong-yu,YAO Ri-sheng.The Synthesis of Ethyl 2-(3-chloro-2-yl)-5-hydroxy-pyrazole-3-carboxylate[J].Anhui Chemical Industry,2014(5):16-17,20. |
| |
| Authors: | YE Jun DUAN Hong-yu YAO Ri-sheng |
| |
| Affiliation: | YE Jun;DUAN Hong-yu;YAO Ri-sheng;School of Medical Engineering,Hefei University of Technology; |
| |
| Abstract: | Ethyl 2-（3-chloro-2-yl ）-5-hydroxy-pyrazole-3-carboxylate is an important intermediate for the synthesis of pesticides chlorantraniliprole. This work described an expedient route and technology for the pyrazole synthesis using 2,3-dichloropyridine as starting material, via hydrazinolysis and cyclization with optimized total yield of 43.1%, and the hydrazinolysis process is simple with solvent-free. |
| |
| Keywords: | ethyl 2- (3-chloro-2-yl)-5-hydroxy-pyrazole-3-carboxylate 3-chloro-2-hydrazino-pyridine synthesis solvent-free method |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
