| 2-噻吩甲酸的环境友好合成工艺 |
| |
| 引用本文： | 郭海昌.2-噻吩甲酸的环境友好合成工艺[J].化工中间体,2007(12):13-14,7. |
| |
| 作者姓名： | 郭海昌 |
| |
| 作者单位： | 台州学院,医药化工学院,浙江,临海,317000 |
| |
| 摘 要： | 以噻吩为原料,经吡啶溴氢酸溴盐溴化得2-溴噻吩,以新型的绿色溶剂2-甲基四氢呋喃为溶剂制备格氏试剂,再和原甲酸三乙酯加成、水解制得2-噻吩甲醛,最后以双氧水氧化得到2-噻吩甲酸。本方法环境友好,总收率达74%。
|
| 关 键 词： | 环境友好 格氏反应 2-噻吩甲醛 2-噻吩甲酸 |
| 文章编号： | 1006-253x（2007）12-013-2 |
The Environmental-friendly Synthesis of 2-Thiophenecarboxylic Acid |
| |
| Authors: | GUO Hai-Chang |
| |
| Affiliation: | GUO Hai-Chang (School of Pharmaceutical and Chemical Engineenng of Taizhou University, LinHai 317000, Zhejiang, China ) |
| |
| Abstract: | 2-Thiophenecarboxylic acid was synthesized from thiophene through bromination with pyri- dine hydrobromide perbromide to give 2-bromothiophene, followed by Grignard reaction in MeTHF as a solvent, then reacted with triethyl orthoformate and hydrolyzed to give 2-thiophenecarboxaldehyde, finally oxided with H202. The synthesis technique was environmental-friendly with an overall yield of 74%. |
| |
| Keywords: | environmental-friendly Grignard reaction 2-thiophenecarboxaldehyde 2-thiophenecar- boxylic acid |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
