A radionuclide-microscopic study of sorption of sodium [3H]succinate on textured nanohydroxyapatite

Specific features of sorption of sodium ³H]succinate on nanohydroxyapatite (HAP) and its hierarchic textures were studied by radionuclide-microscopic diagnostics. Chemisorption of sodium succinate leads to structural-morphological modification of HAP, manifested, in particular, in changes in the habit of individual nanocrystals and in the internal texture of HAP macrospheroids. The dynamics of sorption penetration of sodium succinate into macrospherical HAP granules was monitored by autoradiogarphy. The results obtained suggest that nanohydroxyapatite and textured products based on it can be used for the development of materials for drug transport and of complex succinic acid containing preparations for medical purpose.