| 醋酸催化下枸杞多糖的硒化修饰及抗肿瘤活性 |
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| 引用本文： | 梁淑轩,马二红,赵燕燕,许成燕,孙汉文. 醋酸催化下枸杞多糖的硒化修饰及抗肿瘤活性[J]. 食品研究与开发, 2011, 32(3): 160-164 |
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| 作者姓名： | 梁淑轩 马二红 赵燕燕 许成燕 孙汉文 |
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| 作者单位： | 1. 河北大学,化学与环境科学学院,河北省分析科学重点实验室,河北,保定,071002
2. 河北大学,医学部实验中心,河北,保定,071000 |
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| 基金项目： | 河北省自然科学基金项目，国家自然科学基金项目 |
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| 摘 要： | 制备硒化枸杞多糖,初步了解其结构及体外抗肿瘤活性。利用亚硒酸钠对枸杞多糖进行修饰,通过将无机硒转化为有机硒,为得到高含硒量的枸杞多糖进行探索,找出最佳反应条件为:2mL冰醋酸作为催化试剂,硒化试剂硒酸钠用量为2g,室温下反应时间48h。通过紫外光谱、红外光谱分析,并进行了体外抗肿瘤的初步试验研究。结果:确定了硒化枸杞多糖的分子结构中存在亚硒酸基团,人宫颈癌细胞抑制率可达到26.1%。硒化枸杞多糖对人宫颈癌细胞存在一定的抑制作用。
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| 关 键 词： | 枸杞多糖 硒化枸杞多糖 制备 人宫颈癌细胞 抑制 |
Synthesis of Selenium-containing Lycium Barbarum Polysaccharides and its Antitumor Activity in Vitro |
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| LIANG Shu-xuan,MA Er-hong,ZHAO Yan-yan,XU Cheng-yan,SUN Han-Wen. Synthesis of Selenium-containing Lycium Barbarum Polysaccharides and its Antitumor Activity in Vitro[J]. Food Research and Developent, 2011, 32(3): 160-164 |
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| Authors: | LIANG Shu-xuan MA Er-hong ZHAO Yan-yan XU Cheng-yan SUN Han-Wen |
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| Affiliation: | LIANG Shu-xuan1,MA Er-hong1,ZHAO Yan-yan2,XU Cheng-yan1,SUN Han-wen1(1.College of Chemistry and Environmental Science,Hebei University,Key Laboratory of Analytical Science,Hebei Province,Baoding 071002,Hebei,China,2.Medicine Experimental Center,Baoding 071000,China) |
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| Abstract: | Preparation conditions of selenium-containing Lycium barbarum polysaccharides(LBP) were researched.Structure of the target production and antitumor activity in vitro were determined.Sodium selenite was used as modifying reagent of Lycium barbarum polysaccharide.Inorganic selenium was changed into organic selenium.Reaction conditions were optimized to get high selenium content of Lycium barbarum polysaccharides.2 g Na2SeO3 was added to LBP and catalyzed by 2 mL acetate acid structure of organic selenium was ... |
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| Keywords: | Lycium barbarum polysaccharides selenide Lycium barbarum polysaccharides preparation Human cervical carcinoma cell inhibition |
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