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A Practical Synthesis of α‐Fluoroketones in Aqueous Media by Decarboxylative Fluorination of β‐Ketoacids |
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| Authors: | Jian Li Yin‐Long Li Nan Jin Ai‐Lun Ma Ya‐Nan Huang Jun Deng |
| Abstract: | A practical and novel process for the decarboxylative fluorination of β‐ketoacids in water in the presence of phase transfer catalyst has been developed, affording a series of α‐fluoroketones in good to excellent yields. Furthermore, a preliminary investigation for the catalytic asymmetric transformation was performed and a proposed mechanistic pathway for this catalytic process was proposed.  |
| Keywords: | decarboxylative fluorination phase‐transfer catalysis Selectfluor α ‐fluoroketones β ‐ketoacids |