Cytotoxic O-bridged inert titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands |
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| Affiliation: | 1. Chemistry Department, Faculty of Science, Taif University, Al-Haweiah, P.O. Box 888, 21974 Taif, Saudi Arabia;2. Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt;3. Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt;4. Department of Biochemistry, Faculty of Agriculture, Cairo University, Giza, Egypt;5. Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia;6. Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, 12622 Dokki, Cairo, Egypt |
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| Abstract: | Binuclear O-bridged titanium(IV) complexes of phenylenediamine-bis(phenolato) ligands were obtained from the corresponding ligands and Ti(OiPr)4 and analyzed by 1H, 13C and diffusion NMR. The comparative hydrolytic stability in 1:9 D2O/DMSO-d6 was assessed by 1H NMR, and the complexes featured t1/2 values of above 100 h. The cytotoxic activity of the binuclear complexes was measured toward human colon HT-29 cancer cell line by the MTT assay. Although as expected most complexes exhibited mild or no cytotoxic activity, one leading complex demonstrated marked activity with IC50 value of 77 ± 40 μM. |
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