Synthesis and characterization of dual-stimuli-responsive micelles based on poly(N-isopropylacrylamide) and polycarbonate with photocleavable moieties |
| |
| Affiliation: | 1. Graduate Institute of Natural Products, Chang Gung University, Tao-Yuan, Taiwan;2. Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan;3. Division of Natural Science, Center of General Education, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan 333, Taiwan;1. ETH Zürich, Department of Chemistry and Applied Biosciences, Laboratory of Inorganic Chemistry, Vladimir-Prelog Weg 1, 8093 Zürich, Switzerland;2. Eawag, Swiss Federal Institute of Aquatic Science and Technology, Überlandstrasse 133, CH-8600 Dübendorf, Switzerland |
| |
| Abstract: | Dual-sensitive block copolymers, PNiPAAm-b-PNBTMC, were synthesized via the ring-opening polymerization of 3-methyl-3-nitrobenzyl-trimethylene carbonate (NBTMC) bearing numerous 2-nitro-benzoxycarbonyl photolabile groups with a PNiPAAm macroinitiator in the presence of an organocatalyst, 1,5,7-triazobicyclo-[4.4.0]dec-5-ene (TBD). When the polymer solutions were exposed to ultraviolet (UV) irradiation, we observed significant changes in the structure and morphology of the particles. Fluorescence spectroscopy studies revealed that the copolymers underwent micellization or dissociation transitions in water in response to temperature changes and UV irradiation. No significant toxicity of these nanoparticles was found at concentrations up to 300 μg mL− 1. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
