| 线粒体靶向的积雪草酸稀土配合物的合成及抗肿瘤活性 |
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| 引用本文： | 张蓉仙,朱禹,郭文洁,陈秋云,高静,刘桃涛.线粒体靶向的积雪草酸稀土配合物的合成及抗肿瘤活性[J].化学试剂,2009,31(12). |
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| 作者姓名： | 张蓉仙 朱禹 郭文洁 陈秋云 高静 刘桃涛 |
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| 作者单位： | 1. 江苏大学化学化工学院,江苏,镇江,212013
2. 江苏大学药学院,江苏,镇江,212013 |
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| 基金项目： | 江苏省自然科学基金资助项目，镇江市社会发展计划项目 |
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| 摘 要： | 制备了3种新的稀土配合物LnAA(NO_3)_3·3C_2H_5OH·nH_2O(Ln=La,Ce,Eu,n=1或2).通过元素分析、摩尔电导、红外光谱、差热-热重分析确定了该类配合物的化学组成.研究了积雪草酸稀土配合物与线粒体的相互作用和抑制食管癌细胞(Eca-109)增殖的能力.发现积雪草酸稀土配合物与线粒体有直接作用,且抗肿瘤活性明显强于配体,可能是一类以线粒体为靶点的抗肿瘤化合物.
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| 关 键 词： | 积雪草酸 稀土配合物 抗肿瘤 线粒体 |
Study on the synthesis and antitumor properties of asiatic acid lanthanide complexes to target mitochondria |
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| ZHANG Rong-xian,ZHU Yu,GUO Wen-jie,CHEN Qiu-yun,GAO Jing,LIU Tao-tao.Study on the synthesis and antitumor properties of asiatic acid lanthanide complexes to target mitochondria[J].Chemical Reagents,2009,31(12). |
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| Authors: | ZHANG Rong-xian ZHU Yu GUO Wen-jie CHEN Qiu-yun GAO Jing LIU Tao-tao |
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| Abstract: | Three lanthanide(Ⅲ) complexes LnAA(NO_3)_3·3C_2H_5OH·nH_2O(Ln=La,Ce,Eu,n=1 or 2) were synthesized and characterized by elemental analysis,molar conductivity,IR,and DSC-thermal analysis.The interactions between the complexes with mitochondria and the inhibition of complexes against the proliferation of esophageal cancer cells(Eca-109) were studied.The results showed that the lanthanide(Ⅲ) complexes could inhibit the proliferation of cancer cells and interact with mitochondria directly.So the lanthanide(Ⅲ) complexes could be used as antitumor complexes to target mitochondria. |
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| Keywords: | asiatic acid lanthanide complexes antitumor activity mitochondria |
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