| 液相色谱-串联质谱法测定鱼肉中的七种全氟有机物 |
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| 引用本文： | 罗海英,蔡依军,冼燕萍,吴玉銮,郭新东,陈意光.液相色谱-串联质谱法测定鱼肉中的七种全氟有机物[J].食品工业科技,2011,32(2):325-327,424. |
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| 作者姓名： | 罗海英 蔡依军 冼燕萍 吴玉銮 郭新东 陈意光 |
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| 作者单位： | 广州市质量监督检测研究院,国家加工食品质量监督检验中心(广州),广东广州,510110 |
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| 基金项目： | 国家质量监督检验检疫总局科技计划项目(2008QK264) |
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| 摘 要： | 建立了液相色谱-串联质谱检测鱼肉中七种全氟有机物残留的分析方法。通过优化和比较,样品选用甲醇均质提取,C18固相萃取小柱净化,以乙腈-5mmol/L乙酸铵为流动相经C8反相色谱柱分离后,采用多反应监测(MRM)负离子模式检测。阴性样品添加实验结果表明,特征离子相对强度比值稳定,基质效应干扰少,结合保留时间可实现准确的定性定量,方法检出限为0.01～0.03μg/kg(S/N=3),不同鱼肉基质样本添加水平在0.05～1.0μg/kg时,平均回收率为80.0%～120.0%,相对偏差(n=6)为2.9%～7.6%。
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| 关 键 词： | 液相色谱-串联质谱 鱼 全氟有机物 测定 |
Determination of seven perfluorinated compounds in fish by liquid chromatography-electrospray ionization tandem mass spectrometry |
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| LUO Hai-ying,CAI Yi-jun,XIAN Yan-ping,WU Yu-luan,GUO Xin-dong,CHEN Yi-guang.Determination of seven perfluorinated compounds in fish by liquid chromatography-electrospray ionization tandem mass spectrometry[J].Science and Technology of Food Industry,2011,32(2):325-327,424. |
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| Authors: | LUO Hai-ying CAI Yi-jun XIAN Yan-ping WU Yu-luan GUO Xin-dong CHEN Yi-guang |
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| Affiliation: | LUO Hai-ying,CAI Yi-jun,XIAN Yan-ping,WU Yu-luan,GUO Xin-dong,CHEN Yi-guang (Guangzhou Quality Supervision and Testing Institute,National Center for Quality Supervision and Testing of Cosmetics(Guangzhou),Guangzhou 510110,China) |
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| Abstract: | A high performance liquid chromatography-electrospray ionization-tandem mass spectrometric(HPLC-ESI-MS/MS)method was established for the determination of 7 perfluorinated compounds(PFCs)in fish. The sample was extracted with methanol and cleaned up by C18 SPE cartridges. 7 PFCs were separated on a C8 reversed-phase column using gradient elution with acetonitrile and 5mmol/L ammonium acetate. The tandem mass spectral acquisition was done in the negative electrospray ionization utilizing multiple reaction mon... |
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| Keywords: | HPLCMS/MS fish perfluorinated compounds(PFCs) determination |
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