Effect of medium-chain fatty acid positional distribution in dietary triacylglycerol on lymphatic lipid transport and chylomicron composition in rats |
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Authors: | Octavio Carvajal Masahiro Nakayama Taiji Kishi Masao Sato Ikuo Ikeda Michihiro Sugano Katsumi Imaizumi |
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Affiliation: | (1) Laboratory of Nutrition Chemistry, Division of Bioresource and Bioenvironmental Sciences, Graduate School, Kyushu University, 812-8581 Fukuoka, Japan;(2) Kumamoto Prefecture University, Kumamoto, Japan |
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Abstract: | The present study was carried out to examine if the positional distribution of medium-chain fatty acid (MCF) in dietary synthetic
fat influences lymphatic transport of dietary fat and the chemical composition of chylomicrons in rats with permanent cannulation
of thoracic duct. Four types of synthetic triacylglycerol were prepared: (i) sn-1(3) MCF-sn 2 linoleic acid, (ii) interesterified sn-1(3) MCF-sn 2 linoleic acid, (iii) sn-2 MCF-sn-1(3) linoleic acid, and (iv) interesterified sn-2 MCF-sn-1(3) linoleic acid. A purified diet composed of equal amounts of the synthetic fat and cocoa butter was given to rats with
permanent lymph duct cannulation. The positional distribution of MCF in the dietary fat had no significant effect on the lymph
flow, triacylglycerol output, phospholipid output, lipid composition of chylomicrons, or the particle size. The positional
distribution of MCF in the synthetic triacylglycerol was maintained in the chylomicron triacylglycerol. These results showed
that MCF in the dietary triacylglycerol is transported into lymphatics and the positional distribution is well preserved in
chylomicron triacylglycerol. |
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