Antibacterial activity of new dibenzoxepinone oximes with fluorine and trifluoromethyl group substituents |
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Authors: | Limban Carmen Chifiriuc Mariana Carmen |
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Affiliation: | Pharmaceutical Chemistry Department, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 Traian Vuia, Bucharest 020956, Romania; E-Mail: carmen_limban@yahoo.com. |
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Abstract: | In this paper we present the antimicrobial activity of some newly synthesized dibenzb,e]oxepin derivatives bearing the oximino moiety, and fluorine (F) and trifluoromethyl (CF(3)) group substituents. The chemical structure and purity of the new compounds were assessed by using elemental analysis, NMR and FTIR spectroscopy. The new compounds were screened for their antibacterial activity towards Gram-positive and Gram-negative strains, by qualitative and quantitative assays. Our results demonstrated that the CF(3) and F disubstituted compounds could be considered for the further development of novel antimicrobial drugs. |
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Keywords: | dibenz[b e]oxepin methanone derivatives antibacterial activity gram-positive gram-negative |
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