| 氟化MCM-41的制备及超声触发释药性能研究 |
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| 引用本文： | 张光辉,徐彦芹,曹渊.氟化MCM-41的制备及超声触发释药性能研究[J].材料导报,2011,25(6):62-65. |
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| 作者姓名： | 张光辉 徐彦芹 曹渊 |
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| 作者单位： | 重庆大学化学化工学院; |
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| 基金项目： | “211工程”三期建设项目(S-09103); 重庆大学研究生创新基金项目(201005A1A0010332) |
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| 摘 要： | 采用微波法制备了MCM-41,并将其与NH4F反应制得氟化MCM-41(F-MCM-41),采用浸渍法将抗肿瘤药物5-氟尿嘧啶(5-FU)分别组装到MCM-41和氟化MCM-41中。采用XRD、FT-IR、低温N2吸附和TG对MCM-41、氟化MCM-41和药物组装体进行了表征,考察了常规条件和超声条件下组装体在人工模拟胃液中的药物释放行为。结果表明,药物组装体超声条件下的药物释放速率明显优于常规释放。
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| 关 键 词： | 超声 介孔分子筛 氟化MCM-41 5-FU 释药 |
Preparation of Fluorinated MCM-41 and Properties of Ultrasound to Trigger Release |
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| ZHANG Guanghui,XU Yanqin,CAO Yuan.Preparation of Fluorinated MCM-41 and Properties of Ultrasound to Trigger Release[J].Materials Review,2011,25(6):62-65. |
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| Authors: | ZHANG Guanghui XU Yanqin CAO Yuan |
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| Affiliation: | ZHANG Guanghui,XU Yanqin,CAO Yuan(Institute of Chemistry and Chemical Engineering,Chongqing University,Chongqing 400030) |
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| Abstract: | MCM-41 was synthesized by microwave method.Then fluorinated MCM-41 was synthesized by the reaction of NH4F and MCM-41.Anticancer drugs 5-fluorouracil(5-FU) were assembled into the passway of MCM-41 and fluorinated MCM-41 by the impregnation method.MCM-41,fluorinated MCM-41 and assemblies were charactered by XRD,FT-IR,low temperature N2 adsorption and TG.The drug release of assemblies were investigated under routine condition and ultrasonic condition in artificial gastric juice.The results show that the drug... |
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| Keywords: | ultrasound mesoporous molecular sieve fluorinated MCM-41 5-FU drug release |
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