| 微流控技术制备吡柔比星聚乳酸微球及其体外释放研究 |
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| 引用本文： | 罗婷婷,何天稀,梁琼麟,胡坪,王义明,罗国安. 微流控技术制备吡柔比星聚乳酸微球及其体外释放研究[J]. 材料导报, 2011, 25(8): 30-33,41 |
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| 作者姓名： | 罗婷婷 何天稀 梁琼麟 胡坪 王义明 罗国安 |
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| 作者单位： | 华东理工大学药学院;清华大学化学系;华东理工大学化学与分子工程学院; |
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| 基金项目： | 国家973项目(2007CB714505) |
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| 摘 要： | 微流控液滴技术是制备单分散性药物载体的理想方法,对精确考察药物的释放行为、释放机理及动力学模型具有重要意义。采用亲水性修饰T型通道产生单分散性吡柔比星聚乳酸液滴,考察了通道性质对液滴生成的影响以及连续相和分散相流速与液滴尺寸的关系,制备了两种粒径的吡柔比星聚乳酸微球并考察了其体外释放行为。结果表明,经修饰的通道可产生稳定均一的液滴,通过调节两相流速可以有效控制液滴和微球的尺寸,制备的微球粒径均一,载药量和包封率高,吡柔比星体外释放缓慢且无明显突释,尺寸较大微球的释放速率较慢。
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| 关 键 词： | 微流控 吡柔比星 聚乳酸 微球 体外释放 |
Microfluidic Fabrication of Pirarubicin-loaded Polylactic Acid Microspheres and Its in Vitro Release |
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| LUO Tingting,HE Tianxi,LIANG Qionglin,HU Ping,WANG Yiming,LUO Guoan. Microfluidic Fabrication of Pirarubicin-loaded Polylactic Acid Microspheres and Its in Vitro Release[J]. Materials Review, 2011, 25(8): 30-33,41 |
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| Authors: | LUO Tingting HE Tianxi LIANG Qionglin HU Ping WANG Yiming LUO Guoan |
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| Affiliation: | LUO Tingting1,2,HE Tianxi2,LIANG Qionglin2,HU Ping3,WANG Yiming2,LUO Guo'an1,2(1 School of Pharmacy,East China University of Science and Technology,Shanghai 200237,2 Department of Chemistry,Tsinghua University,Beijing 100084,3 School of Chemistry and Molecular Engineer,East China University of Scienceand Technology,Shanghai 200237) |
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| Abstract: | Droplet microfluidic approach is an ideal way to prepare monodisperse drug carriers,which have significance to study the release behavior,mechanism and kinetic model of drug.The monodisperse pirarubicin-loaded polylactic microspheres were prepared using hydrophilic modified T-junction microchannel device,the impact of channel property on the microdroplets preparation was studied,and the relationship between flow rate of continuous phase and dispersed phase and droplets size were investigated.Two different s... |
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| Keywords: | microfluidic pirarubicin polylactic microsphere in vitro release |
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