Neurotrophic activity of organosulfur compounds having a thioallyl group on cultured rat hippocampal neurons |
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| Authors: | T Moriguchi H Matsuura Y Kodera Y Itakura H Katsuki H Saito N Nishiyama |
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| Affiliation: | Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan. |
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| Abstract: | Several organosulfur compounds found in garlic extract promoted the survival of rat hippocampal neurons in vitro. From the analysis of structure-activity relationship, thioallyl group in these compounds is essential for the manifestation of neurotrophic activity. S-Allyl-L-cysteine (SAC), one of the organosulfur compounds having thioallyl group in garlic extract, also promoted the axonal branching of cultured neurons. These results suggest that thioallyl compounds make a unique group of neurotrophic factors. |
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