| 青霉烯类抗生素及其构效关系 |
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| 引用本文： | 白云峰,李士杰,贾荣荣.青霉烯类抗生素及其构效关系[J].河北化工,2004,27(6):10-12,27. |
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| 作者姓名： | 白云峰 李士杰 贾荣荣 |
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| 作者单位： | [1]五四八厂，河北石家庄050031 [2]华北制药倍达有限公司，河北石家庄050031 |
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| 摘 要： | 青霉烯是一类抗菌谱广、抗菌活性高、对肾脱氢肽酶-Ⅰ稳定的抗生素。介绍了青霉烯类抗生素的特征、抗菌性及其活性的构效关系，及用分子力学和分子轨道方法对其构效关系进行的理论阐述。
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| 关 键 词： | 青霉烯 抗生素 抗菌活性 构效关系 计算方法 |
Generality of Research of Penem Antibiotic and Its Structure-activity |
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| BAI Yun-feng,LI Shi-jie,JIA Rong-rong.Generality of Research of Penem Antibiotic and Its Structure-activity[J].Hebei Chemical Engineering and Industry,2004,27(6):10-12,27. |
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| Authors: | BAI Yun-feng LI Shi-jie JIA Rong-rong |
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| Abstract: | Penem antibiotic have broad-spectrum and strong antimicrobial activity,but have the stability to DHP-I.This paper introduce its character,antibiotic property and its relationship of structure-activity, the molecule-mechanical and molecule orbit method which elucidate the relationship of structure-activity abstractly. |
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| Keywords: | penem antibiotie antimicrobial activity relationship of structure-activity method |
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