超临界流体技术制备中药超细粉体

颗粒细、药效好、用量少已成为现代中药制剂的必然发展趋势。利用近年提出的超临界流体辅助雾化过程成功制备出了中药复方肝炎制剂的超细粉体,系统分析了混合器压力和温度及进液速率对微粒形态、粒径和粒径分布的影响。结果表明：利用超临界辅助雾化过程,以水和乙醇的混合溶液为溶剂,可制备出粒径范围为1.0～5.0μm的复方肝炎超细粉体,且大部分粒子形态呈完整的球形。各影响因素对粒径及粒径分布均有不同程度的影响,其中混合器压力及溶液浓度对粒径及粒径分布的影响最明显,进液速率次之,混合器温度的影响较小。在操作范围内较为理想的工艺条件为混合器压力为14 MPa,温度为60℃,进液速率为4.5 mL/min。

Preparation of Chinese medicine ultrafine particles by supercritical fluid technique

Ultrafine particles, good efficiency and small dose have become an inevitable development trend for modern Chinese medicine. In this paper, the ultrafine particles of compound Chinese medicine for hepatitis are prepared by successfully by supereritical fluid expansion depressurization process developed in recent years. The influences of the operation parameters, including the pressure and temperature in the mixing vessel and the solution feed rate, on the particle morphology,diameter and diameter distribution are investigated in detail. The results show that, ultrafine particles of compound Chinese medicine for hepatitis between 1-5μm can be prepared by using the mixture of water and ethanol as initial solvent. Most of the particles are welbdefined spherical in morphology. The different process parameters have different influences on particle size and particle size distribution. The pressure in the mixing vessel is the most effective parameter, the solution feed rate is the next, and the temperature in the mixing vessel has little influence. The optimal operation condition for preparing ultrafine particles in the range of this work is the pressure 14 MPa, the temperature 60℃ in the mixing vessel, and the solution feed rate 4.5 mL/min.