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The long chain α–tocopherol metabolite α‐13’‐COOH and γ‐tocotrienol induce P‐glycoprotein expression and activity by activation of the pregnane X receptor in the intestinal cell line LS 180 |
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| Authors: | Maren C. Podszun Metta Jakobi Marc Birringer Johanna Weiss Jan Frank |
| Affiliation: | 1. Institute of Biological Chemistry and Nutrition, University of Hohenheim, Stuttgart, Germany;2. Department of Nutritional, Food and Consumer, University of Applied Sciences, Fulda, Germany;3. Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Germany |
| Abstract: | |
| Keywords: | Alpha‐tocopherol Alpha‐13’ ‐COOH PC‐8, P‐glycoprotein PXR / Vitamin E |