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Parametric analysis of shape changes of alginate beads
Authors:Pujiang Shi  Thomas K.H. Teh  James C.H. Goh
Affiliation:
  • a Department of Orthopedic Surgery, National University of Singapore, 10 Lower Kent Ridge Road, Singapore 119260, Singapore
  • b Division of Bioengineering, National University of Singapore, Singapore
  • c Bio-mechanical and Tissue Engineering, Faculty of Engineering and Industrial Sciences, Swinburne University of Technology, Hawthorn VIC3122, Australia
  • Abstract:In this article, the various elements controlling the geometry of alginate beads such as voltage, solution concentrations and extrusive rates were experimentally investigated. The findings indicated that the combination of higher voltages more concentrated CaCl2 solutions, shorter width of electrical field and slower extrusive rates can permit the alginate beads to become smaller. Also the effect of the electrical forces that acted on the liquid droplets was found to be stronger than that of the gravity forces did. The alginate solution concentration was found to influence the beads' shape significantly. Lower concentration of 0.5% resulted in tear-like beads arrangements and a higher concentration of 5 and 8% produced pear-like and sperm-like beads configurations. In addition to obtain special alginate beads, such as elliptical and bullet like beads, outside force could be applied. The above findings could open a broad gate for future control release system developments.
    Keywords:Alginate bead   Shape   Control release system   Gelation   Voltage
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