| β-环糊精手性流动相HPLC法拆分α-环己基扁桃酸对映体 |
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| 引用本文： | 胡珊珊,吴怡祖,史美仁.β-环糊精手性流动相HPLC法拆分α-环己基扁桃酸对映体[J].精细化工,2004,21(10):731-732,740. |
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| 作者姓名： | 胡珊珊 吴怡祖 史美仁 |
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| 作者单位： | 南京工业大学,化学化工学院,江苏,南京,210009 |
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| 摘 要： | 以β 环糊精为手性流动相添加剂,于C18柱高效液相色谱上建立了α 环己基扁桃酸对映体的拆分方法。调整流动相配比,使其S型与R型对映体保留时间分别由文献值70min和85min缩短到7 83min和8 83min。最佳拆分条件为:β 环糊精浓度为9 5mmol/L;流动相组成及其比例为V〔c(KH2PO4)=0 075mol/L水溶液〕∶V(乙醇)∶V(乙腈)=65∶20∶15;流量为1mL/min;温度为室温。
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| 关 键 词： | β-环糊精 α-环己基扁桃酸 高效液相色谱 流动相添加剂 对映体 |
| 文章编号： | 1003-5214(2004)10-0731-03 |
Resolution of α-Cyclohexyl-mandelic Acid into Enantiomers by HPLC with β-Cyclodextrin as Additive in Mobile Phase |
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| HU Shan-shan,WU Yi-zu,SHI Mei-ren.Resolution of α-Cyclohexyl-mandelic Acid into Enantiomers by HPLC with β-Cyclodextrin as Additive in Mobile Phase[J].Fine Chemicals,2004,21(10):731-732,740. |
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| Authors: | HU Shan-shan WU Yi-zu SHI Mei-ren |
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| Affiliation: | HU Shan-shan,WU Yi-zu,SHI Mei-ren~* |
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| Abstract: | The method of resolution of α-cyclohexyl-mandelic acid by HPLC with β-cyclodextrin as an additive in the mobile phase on C_(18) column was introduced.The retention times of the S and R enantiomers were reduced from the literature-cited values 70 min and 85 min to 7.83 min and 8.83 min respectively.The premium conditions of resolution of α-cyclohexyl-mandelic acid were concentration of β-cyclodextrin 9.5 mmol/L,composition and percentage of the mobile phase V〔(aqueous KH_2PO_4 solution(0.075 mol/L)〕∶V(ethanol)∶V(acetonitrile)=65∶20∶15,flow rate 1 mL/min and room temperature. |
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| Keywords: | β-cyclodextrin α-cyclohexyl-mandelic acid HPLC mobile phase additive enantiomer |
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