Post-laparoscopic vomiting in females versus males: comparison of prophylactic antiemetic action of ondansetron versus metoclopramide

PURPOSE: To evaluate the clinical usefulness of the continuous intra-arterial blood gas (CIABG) monitoring system, Paratrend 7, during differential lung ventilation (DLV) in 12 patients undergoing oesophagectomy. METHODS: Anaesthesia was induced with propofol and was maintained with isoflurane, oxygen and air, supplemented by an epidural infusion of mepivacaine. Arterial samples for estimation of blood gases (ABG) were taken just before and 5, 10, 20, 30, 60, and 90 min after the pleura was opened. The pH, PO2, and PCO2 values displayed by the CIABG monitor, which were recorded prior to the arterial blood sampling, were compared with the results of ABG analysis. RESULTS: Eighty-four blood samples were obtained and the ranges for the measured variables were PCO2 24.8-57.4 mmHg, PO2 47-449 mmHg, and pH 7.30-7.49. The correlation between CIABG and ABG measurements was strong and significant (r values: PCO2 0.80, PO2 0.93, pH 0.94). The overall bias +/- precision between the two methods was PCO2 0.9 +/- 3.1 mmHg, PO2 -1 +/- 40 mmHg, %PO2 0.8 +/- 21.6%, pH 0.00 +/- 0.02. For PO2 values < 150 mmHg, the biases +/- precision were PO2 -5 +/- 17 mmHg, %PO2 -2.1 +/- 20.7%. CONCLUSION: The agreement between CIABG and ABG measurements was better for PCO2 and pH than for PO2. Although the CIABG system is clinically useful for monitoring trends in blood gas changes, the accuracy of the PO2 value may be unacceptable during DLV because the error is theoretically < 34 mmHg with 95% reliability in the clinically important range of PO2, < 150 mmHg.