Evidence for McKusick''s hypothesis of deficient collagen cross-linking in patients with homocystinuria |
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Authors: | B Lubec S Fang-Kircher T Lubec HJ Blom GH Boers |
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Affiliation: | Laboratório de Neurofarmacologia-Departamento de Farmacologia, ICB Universidade Federal de Minas Gerais, Belo Horizonte-MG, Brazil. mromano@icb.ufmg.br |
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Abstract: | Fractionation of the venom of the spider Phoneutria nigriventer revealed that it was a mixture of several neurotoxic peptides. The peptides so far characterized either inhibited or induced neurotransmitter release. These effects were mediated by Ca2+ channels or increasing Na+ permeability through voltage sensitive Na(+)-channels, respectively. The pooled toxic components (fraction P4) showed stimulatory effects on acetylcholine release from brain cortical slices. In addition, a component of the observed effects resembling that of alpha-latrotoxin was identified, which was characterized by the ability to provoke release of acetylcholine (ACh) at low temperature and in a manner independent of extracellular Ca2+ and of voltage sensitive Na(+)-channels. |
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