In vitro activity of the new ketolide HMR3647 in comparison with those of macrolides and pristinamycins against Enterococcus spp |
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Authors: | C Torres M Zarazaga C Tenorio A Portillo Y Saenz F Ruiz F Baquero |
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Affiliation: | Area de Bioquímica y Biología Molecular, Universidad de La Rioja, Logro?o, Spain. carmen.torres@daa.unirioja.es |
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Abstract: | Ninety-four erythromycin-susceptible and 107 erythromycin-resistant enterococcal strains (MIC of >/=512 microgram/ml) were inhibited by the ketolide HMR3647 at MICs of =0.007 to 0.06 and 0.03 to 8 microgram/ml, respectively. Eighteen vanA-positive isolates and 29 high-level-penicillin-resistant isolates, all of them erythromycin resistant, were inhibited by HMR3647 at an MIC range of 0.015 to 4 microgram/ml. The new ketolide has excellent activity against Enterococcus species. |
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