Recent advances in brain cholesterol dynamics: Transport, domains, and Alzheimer's disease |
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| Authors: | W. Gibson Wood Friedhelm Schroeder Nicolai A. Avdulov Svetlana V. Chochina Urule Igbavboa |
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| Affiliation: | (1) Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, GRECC, 11G, 55417 Minneapolis, Minnesota;(2) Department of Pharmacology, University of Minnesota School of Medicine, 55417, Minnesota, Minneapolis;(3) Department of Physiology and Pharmacology, Texas A&M University, IVMC, 77843 College Station, Texas |
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| Abstract: | Major advances in understanding cholesterol dynamics and the role that cholesterol plays in vascular disease have recently been made. The brain is an organ that is highly enriched in cholesterol, but progress toward understanding brain cholesterol dynamics has been relatively limited. This review examines recent contributions to the understanding of brain cholesterol dynamics, focusing on extracellular and intracellular lipid carrier proteins, membrane cholesterol domains, and emerging evidence linking an association between cholesterol dynamics and Alzheimer's disease. |
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