| N-((S)-1-乙氧羰基-3-苯丙基)-L-丙氨酸的合成 |
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| 引用本文： | 张丽洁,石强,姬明理,崔荣,张创军,胡琳琳. N-((S)-1-乙氧羰基-3-苯丙基)-L-丙氨酸的合成[J]. 化工技术与开发, 2011, 40(4): 11-12,29 |
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| 作者姓名： | 张丽洁 石强 姬明理 崔荣 张创军 胡琳琳 |
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| 作者单位： | 西安近代化学研究所,陕西,西安,710065 |
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| 摘 要： | 以L-丙氨酸、3-苯甲酰基丙烯酸乙酯等为原料,通过Michael加成反应,制得中间体N-((S)-1-乙氧羰基-3-氧代-3-苯丙基)-L-丙氨酸,进而在钯-碳催化下进行氢化反应,得到目标产物N-((S)-1-乙氧羰基-3-苯丙基)-L-丙氨酸(ECPPA),收率90%;用红外、核磁共振、元素分析等方法对其结构进行表征...
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| 关 键 词： | ECPPA 合成 Michael加成 氢化反应 |
Synthesis of N-((S)-1-ethoxycarbonyl-3-phenylpropyl)-L-alanine |
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| ZHANG Li-jie,SHI Qiang,JI Ming-Li,CUI Rong,ZHANG Chuang-Jun,HU Lin-Lin. Synthesis of N-((S)-1-ethoxycarbonyl-3-phenylpropyl)-L-alanine[J]. Technology & Development of Chemical Industry, 2011, 40(4): 11-12,29 |
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| Authors: | ZHANG Li-jie SHI Qiang JI Ming-Li CUI Rong ZHANG Chuang-Jun HU Lin-Lin |
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| Affiliation: | (Xi’an Modern Chemistry research Institute,Xi’an 710065,China) |
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| Abstract: | The intermediateN-((S)-1-ethoxycarbonyl-3-oxo-3-phenylpropyl)-L-alanine(ECOPPA)was prepared by Michael addition with L-alanine and 3-Benzoylacrylic acid ethyl ester as primary materials.The title compounds N-((S)-1-ethoxycarbonyl-3-phenylpropyl)-L-alanine(ECPPA)was obtained by ECOPPA reacted with Pd-C catalyst in a solvent by hydrogenation with the yield of 90%.Their structures were characterized by IR,NMR andelemental analysis. |
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| Keywords: | ECPPA |
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