| 1,2-双(2-氨基-1,3,4-噻二唑-5基)乙烷的合成工艺研究 |
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| 引用本文： | 贺双艳,陈宝泉,罗振华,李迎辉. 1,2-双(2-氨基-1,3,4-噻二唑-5基)乙烷的合成工艺研究[J]. 精细石油化工, 2012, 29(1): 49-51 |
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| 作者姓名： | 贺双艳 陈宝泉 罗振华 李迎辉 |
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| 作者单位： | 天津理工大学化学化工学院,天津,300384 |
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| 基金项目： | 国家自然科学基金资助项目 |
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| 摘 要： | 实验以氨基硫脲和丁二酸为原料,在多聚磷酸催化下合成了1,2-双(2-氨基-1,3,4-噻二唑-5-基)乙烷,考察了反应条件对收率的影响。最佳反应条件为:n(多聚磷酸)∶n(丁二酸)=2.1∶1,反应温度120℃,反应时间20h,n(丁二酸)∶n(氨基硫脲)=1∶2.2,收率74.6%。产物结构经元素分析、IR、1 H-NMR及ESI-MS等方法进行了确证。
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| 关 键 词： | 1,2-双(2-氨基-1,3,4-噻二唑-5-基)乙烷 氨基硫脲 丁二酸 多聚磷酸 合成 |
SYNTHESIS OF 1,2-BIS (2-AMINO-1 , 3,4-THIADIAZOL-5-YL) EHTANE |
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| He Shuangyan , Chen Baoquan , Luo Zhenhua , Li Yinghui. SYNTHESIS OF 1,2-BIS (2-AMINO-1 , 3,4-THIADIAZOL-5-YL) EHTANE[J]. Speciality Petrochemicals, 2012, 29(1): 49-51 |
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| Authors: | He Shuangyan Chen Baoquan Luo Zhenhua Li Yinghui |
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| Affiliation: | (College of Chemistry and Chemical Engineering,Tianjin University of Technology,Tianjin 300384,China) |
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| Abstract: | 1,2-Bis[2-amino-1,3,4-oxadiazol-5-yl]ethane was synthesized from thiosemicarbazide and succinic acid in the presence of catalyst.The optimal reaction conditions were found as follows: polyphosphoric acid as the catalyst and the usage being 2.1 times of succinic acid,reaction temperature 120 ℃ and reaction time 20 h.The total yield could reached 74.6%.The target compound was indentified by elemental analysis,IR,1H NMR and ESI-MS. |
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| Keywords: | 1,2-bis[2-amino-1,3,4-oxadiazol-5-yl]ethane thiosemicarbazide succinic acid polyphosphoric acid synthesis |
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