| 2-氨基-3,5-二溴二苯甲酮的合成工艺 |
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| 引用本文： | 林富荣,王亚,颉林,周永生.2-氨基-3,5-二溴二苯甲酮的合成工艺[J].精细石油化工,2012,29(2):31-34. |
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| 作者姓名： | 林富荣 王亚 颉林 周永生 |
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| 作者单位： | 常州大学江苏精细石油化工重点实验室,江苏常州,213164 |
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| 摘 要： | 实验以苯和邻氨基苯甲酸为原料,经C-酰基化得2-氨基二苯甲酮,再溴化合成目标产物2-氨基-3,5-二溴二苯甲酮。研究了工艺条件对反应的影响。2-氨基二苯甲酮的适宜工艺条件为:反应温度80℃,反应时间9～10h,n(苯)∶n(邻氨基苯甲酸)=8∶1,收率可达63.1%,纯度为98.9%。2-氨基-3,5-二溴二苯甲酮的适宜工艺条件为:反应温度38～42℃,反应时间2～2.5h,n(2-氨基二苯甲酮)∶n(溴素)=1∶2.5,收率可达86.0%,纯度为95.5%,熔点为97.1～97.8℃。
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| 关 键 词： | 2-氨基-3 5-二溴二苯甲酮 2-氨基二苯甲酮 C-酰基化 溴化 |
SYNTHESIS OF 2-AMINO-3,5-DIBROMOBENZOPHENONE |
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| Lin Furong
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Wang Ya
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Xie Lin
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Zhou Yongsheng.SYNTHESIS OF 2-AMINO-3,5-DIBROMOBENZOPHENONE[J].Speciality Petrochemicals,2012,29(2):31-34. |
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| Authors: | Lin Furong Wang Ya Xie Lin Zhou Yongsheng |
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| Affiliation: | (Jiangsu Key Lab of Fine Petrochemical Engineering,Changzhou University, Changzhou 213164,Jiangsu,China) |
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| Abstract: | 2-Amino-3,5-dibromobenzophenone was prepared via C-acylation and bromination using benzene and 2-aminobenzoic acid as raw materials.The effect of reaction conditions on reaction was studied.It has been shown that under the following optimum conditions: reaction temperature 80 ℃,reaction time 9-10 h and the molar ratio of benzene to 2-amino-benzoic acid of 8∶1,the yield of 2-aminobenzophenone can be up to 63.1% with the purity of 98.9%.The yield of 2-amino-3,5-dibromobenzophenone can be up to 86.0% the purity of 95.5% under the following conditions: reaction temperature 38-42 ℃,reaction time 2-2.5 h and the molar ratio of intermediate to bromize of 1∶2.5.The structure of the product is characterized by 1H NMR with the melting point of 97.1-97.8 ℃. |
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| Keywords: | 2-amino-3 5-dibromobenzophenone 2-aminobenzophenone C-acylation bromination |
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