| 盐酸二甲双胍的平衡溶解度及表观油/水分配系数的测定 |
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| 引用本文： | 陈建福,施伟梅,林洵,陈健旋. 盐酸二甲双胍的平衡溶解度及表观油/水分配系数的测定[J]. 精细石油化工进展, 2012, 13(3): 55-58 |
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| 作者姓名： | 陈建福 施伟梅 林洵 陈健旋 |
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| 作者单位： | 1. 漳州职业技术学院食品与生物工程系,漳州,363000
2. 赣南医学院药学院,赣州,341000 |
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| 基金项目： | 福建省教育厅科技计划研究项目，漳州职业技术院科研计划资助项目，赣南医学院科研课题 |
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| 摘 要： | 建立了紫外分光光度法测定盐酸二甲双胍含量的方法,采用水浴恒温振荡摇瓶法测定盐酸二甲双胍在37℃、不同pH值缓冲液中的平衡溶解度及表观油/水分配系数.结果表明,盐酸二甲双胍在不同pH值下均属于易溶药物；随着pH值升高,盐酸二甲双胍的平衡溶解度增大,而油/水分配系数有减小的趋势,在pH为2.0时的油/水分配系数是pH为8.0时的1.2倍.
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| 关 键 词： | 盐酸二甲双胍 平衡溶解度 分配系数 测定方法 |
Determination of Equilibrium Solubility and Apparent Oil/Water Partition Coefficient of Metformin Hydrochloride |
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| Chen Jianfu , Shi Weimei , Lin Xun , Chen Jianxuan. Determination of Equilibrium Solubility and Apparent Oil/Water Partition Coefficient of Metformin Hydrochloride[J]. Advances in Fine Petrochemicals, 2012, 13(3): 55-58 |
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| Authors: | Chen Jianfu Shi Weimei Lin Xun Chen Jianxuan |
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| Affiliation: | 1(1.Department of Food and Biology Engineering,Zhangzhou Institute of Technology,Zhangzhou 363000;2.College of Pharmacy,Gannan Medical University,Ganzhou 341000) |
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| Abstract: | A quantitative determination method for metformin hydrochloride by ultraviolet spectrophotometry(UV) was established.A shake flask in constant temperature water bath was applied to determine the equilibrium solubility and apparent oil/water partition coefficient of metformin hydrochloride at 37 ℃ in buffer solutions with different pH values.The results showed that metformin hydrochloride was easily soluble in solutions with different pH values and the equilibrium solubility increased and the apparent oil/water partition coefficient decreased with the increase of pH value of buffer solution.The apparent oil /water partition coefficient of metformin hydrochloride in buffer solution with pH value of 2 was 1.2 times that in buffer solution with pH value of 8. |
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| Keywords: | metformin hydrochloride equilibrium solubility partition coefficient determination method |
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