Aortic valves are antigenic but less so than myocardium |
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Authors: | M Kawauchi J Nakajima M Takeda T Oka S Takamoto |
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Affiliation: | Department of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo, Japan. junk@chem.agr.hokudai.ac.jp |
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Abstract: | An aqueous methanol extract from green tea showed potent acetyl-CoA carboxylase inhibitory activity. An active compound was isolated from the extract and identified as (-)-epigallocatechin gallate by instrumental analyses. The IC50 value of (-)-epigallocatechin gallate was 3.1 x 10(-4) M. Among tea catechins and related compounds, nearly equal activity was found in (-)-epigallocatechin gallate and (-)-epicatechin gallate, whereas (+)-catechin, (-)-epicatechin, (-)-epigallocatechin, gallic acid and methyl gallate each had no inhibitory activity. These results indicate that the 3-O-gallate group of the catechin structure was necessary for this activity. (-)-Epigallocatechin gallate inhibited triglyceride accumulation in 3T3-L1 cells at a concentration of 1.0 x 10(-7) M or higher. |
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