Potential tissue implants from the networks based on 1,5-dioxepan-2-one and ε-caprolactone |
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Authors: | Natalia Andronova |
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Affiliation: | Fiber and Polymer Technology, School of Chemical Science and Engineering, Royal Institute of Technology, Stockholm SE-1000 44, Sweden |
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Abstract: | The synthesis and characterization of degradable polymeric networks for biomedical applications was performed. Cross-linked films of poly(ε-caprolactone) (PCL) and poly(1,5-dioxepan-2-one) (PDXO) having various mole fractions of monomers and different cross-link densities were successfully prepared using 2,2′-bis-(ε-caprolactone-4-yl) propane (BCP) as cross-linking agent. Reaction parameters were carefully examined to optimise the film-forming conditions. Networks obtained were elastomeric materials, easy to cast and remove from the mould. Effect of CL content and cross-link density on the final properties of the polymer network was evaluated. High CL content or degree of cross-linking led to increase in Young's modulus and decrease in elongation at break. An increase in crystalline domains in films having a higher CL content was observed by optical microscopy. A greater thermal stability was observed in films having a high CL content. The hydrophilicity of the materials could be tailored by changing the CL content. The surface of the films became rougher with higher CL content. |
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Keywords: | 1,5-Dioxepan-2-one ε-Caprolactone 2,2&prime -Bis-(ε-caprolactone-4-yl) propane |
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