| 3,4-二氨基-1,8-萘酐的合成与结构表征 |
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| 引用本文： | 许东芳,柳清.3,4-二氨基-1,8-萘酐的合成与结构表征[J].应用化工,2006,35(10):779-780. |
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| 作者姓名： | 许东芳 柳清 |
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| 作者单位： | 上海师范大学,生命与环境科学学院,上海,200234 |
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| 摘 要： | 设计合成了3,4-二氨基-1,8-萘酐,以苊作为原料,经过硝化、还原、乙酰化、氧化等七步反应合成的3,4-二氨基-1,8-萘酐,其总收率为11.2%。并用HPLC验证纯度,纯度为98.95%。该化合物作为前体化合物,可继续合成一系列新型萘酰亚胺类抗肿瘤药物。化合物结构均经1H NMR和GC-MS等表征。
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| 关 键 词： | 3 4-二氨基-1 8-萘酐 萘酰亚胺 合成 |
| 文章编号： | 1671-3206(2006)10-0779-02 |
| 收稿时间： | 2006-07-17 |
| 修稿时间： | 2006年7月17日 |
Synthesis and structural characterization of 3,4-diamino-1,8-anhydride naphthalene |
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| XU Dong-fang,LIU Qing.Synthesis and structural characterization of 3,4-diamino-1,8-anhydride naphthalene[J].Applied chemical industry,2006,35(10):779-780. |
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| Authors: | XU Dong-fang LIU Qing |
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| Affiliation: | College of Life and Environment Science ,Shanghai Normal University, Shanghai 200234 ,China |
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| Abstract: | In this thesis,3,4-diamino-1,8-anhydride n aphthalene was designed and synthesized.Using acenaphthene as the reactant,3,4-diamino-1,8-anhydride naphthalene was prepared by seven steps reaction,includi ng nitroreaction,reduction reaction,acetylization reaction and oxidation reacti on and so on,and the total yield was 11.2%,and the purity of it was characterize d by HPLC which reached 98.95%.As prece-ding compound,3,4-diamino-1,8-anhydr ide naphthalene could synthesize a series of novel bisnaphthalimides antitumor d rugs.The structure of these compounds were confirmed by ~1H NMR,GC-MS. |
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| Keywords: | 3 |
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